| Date | Location | Result | |
| 03/04/22 | Asheville, NC | Mercer 81, Western Caro. 53 | Box score |
| 02/26/22 | Cullowhee, NC | Western Caro. 82, VMI 73 | Box score |
| 02/23/22 | Greensboro, NC | UNC Greensboro 73, Western Caro. 64 | Box score |
| 02/19/22 | Cullowhee, NC | Western Caro. 69, Mercer 65 | Box score |
| 02/16/22 | Cullowhee, NC | Furman 103, Western Caro. 85 | Box score |
| 02/12/22 | Spartanburg, SC | Wofford 69, Western Caro. 57 | Box score |
| 02/09/22 | Chattanooga, TN | Chattanooga 65, Western Caro. 47 | Box score |
| 02/07/22 | Cullowhee, NC | UNC Greensboro 68, Western Caro. 49 | Box score |
| 02/04/22 | Lexington, VA | VMI 76, Western Caro. 69 | Box score |
| 02/02/22 | Cullowhee, NC | Western Caro. 87, ETSU 84 | Box score |
| 01/29/22 | Cullowhee, NC | Samford 74, Western Caro. 64 | Box score |
| 01/26/22 | Charleston, SC | The Citadel 68, Western Caro. 66 | Box score |
| 01/22/22 | Macon, GA | Mercer 72, Western Caro. 64 | Box score |
| 01/19/22 | Greenville, SC | Furman 88, Western Caro. 50 | Box score |
| 01/15/22 | Cullowhee, NC | Wofford 84, Western Caro. 64 | Box score |
| 01/12/22 | Cullowhee, NC | Western Caro. 70, Chattanooga 59 | Box score |
| 01/10/22 | Johnson City, TN | ETSU 87, Western Caro. 69 | Box score |
| 01/08/22 | Homewood, AL | Samford 85, Western Caro. 60 | Box score |
| 01/05/22 | Cullowhee, NC | Western Caro. 94, The Citadel 90 (OT) | Box score |
| 12/22/21 | Charlotte, NC | Charlotte 98, Western Caro. 82 | Box score |
| 12/20/21 | Athens, GA | Georgia 85, Western Caro. 79 | Box score |
| 12/11/21 | Cullowhee, NC | UNC Asheville 73, Western Caro. 72 | Box score |
| 12/08/21 | Cullowhee, NC | Western Caro. 74, Tennessee Tech 69 (OT) | Box score |
| 12/04/21 | Spartanburg, SC | Western Caro. 78, USC Upstate 73 | Box score |
| 12/01/21 | Cullowhee, NC | Western Caro. 102, Warren Wilson 47 | Box score |
| 11/27/21 | Boiling Springs, NC | Gardner-Webb 87, Western Caro. 59 | Box score |
| 11/21/21 | Farmville, Va. (Willett Hall) | Western Caro. 64, Longwood 53 | Box score |
| 11/20/21 | Farmville, Va. (Willett Hall) | Western Caro. 80, American 79 | Box score |
| 11/19/21 | Farmville, Va. (Willett Hall) | UMBC 91, Western Caro. 75 | Box score |
| 11/14/21 | Greenville, NC | East Carolina 95, Western Caro. 79 | Box score |
| 11/12/21 | Winston-Salem, NC | Wake Forest 87, Western Caro. 75 | Box score |
| 11/09/21 | Cullowhee, NC | Western Caro. 79, Bowling Green 71 (OT) | Box score |